Absorption, transport, and tissue delivery of vitamin E

Review

Absorption,transport,and tissue delivery

of vitamin E

Attilio Rigotti *

Departamento de Gastroenterolog?

′a,Facultad de Medicina,Ponti?cia Universidad Cato ′lica,Hospital UC,Marcoleta 367,Santiago,Chile

Received 19December 2006;accepted 2January 2007

Abstract

Vitamin E is one of the most abundant lipid-soluble antioxidant agents found in plasma and cells of higher mammals.The uptake,transport and tissue delivery of a -tocopherol,a key vita-min E form,involves molecular,biochemical,and cellular processes closely related to overall lipid and lipoprotein homeostasis.This review highlights recent ?ndings that have led to a better understanding of vitamin E transport,including intestinal absorption,hepatic transport,and cellular uptake of a -tocopherol in vivo.This new information may be critical for manipulation of vitamin E homeostasis in a variety of oxidative stress-related disease conditions in humans.ó2007Elsevier Ltd.All rights reserved.

Keywords:a -Tocopherol;Intestinal absorption;Lipoprotein metabolism;Liver;ABC transporters;LDL receptor;SR-BI

Contents

1.

Introduction .................................................4242.

Intestinal absorption of vitamin E..................................4243.

Plasma lipoprotein transport of vitamin E ............................4270098-2997/$-see front matter ó2007Elsevier Ltd.All rights reserved.doi:10.1016/j.mam.2007.01.002

*Tel.:+5626863832;fax:+5626397780.

E-mail address:arigotti@med.puc.cl

Absorption, transport, and tissue delivery of vitamin E

http://m.wendangku.net/doc/0704e784284ac850ad0242ec.html/locate/mam

Available online at http://m.wendangku.net/doc/0704e784284ac850ad0242ec.html

Molecular Aspects of Medicine 28(2007)

Absorption, transport, and tissue delivery of vitamin E

423–436

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