基于合成方法学研究的有机化学实验教学改革与实践——以苯甲酸乙

?教学研究与改革?https://www.wendangku.net/doc/2f6755986.html,

大学化学(Daxue Huaxue )Univ.Chem.2017,32(7),23－27

July doi:10.3866/PKU.DXHX201701002*通讯作者，Email:hanjie@https://www.wendangku.net/doc/2f6755986.html,

#2015级化学伯苓试验班本科生，排名按姓氏拼音顺序

基金资助：2017年度教育部“基础学科拔尖学生培养试验计划”研究课题(20170109)；南开大学2015年教学改革项目基于合成方法学研究的有机化学实验教学改革与实践

——以苯甲酸乙酯制备为例

陈淼#

陈永嘉#丁尔东#戴畅航#房璠#高凯旻#霍佳彤#江晓宇#

江子渊#李阳#李智豪#李隗星月#刘子琛#汤天化#王昶#张澍堃#郑辛平#宗家睿#刘硕李玉新韩杰*

(南开大学化学学院，化学国家级实验教学示范中心，天津300071)

摘要：以苯甲酸乙酯的制备实验为例，将合成方法学研究引入有机化学实验教学。采取抽签方式确定每个学生的实验内容，通过考查加热方式(电热套或微波辐射加热)、溶剂(甲苯或环己烷)以及反应时间对实验结果的影响，使学生了解科学研究的方法，并通过文献查阅及实验结果分析讨论等教学实践环节提高学生的创新思维和科研能力。

关键词：合成方法学；创新能力；教学改革

中图分类号：G64；O6-33

Teaching Reform and Practice of Organic Chemistry Laboratory Course Based on “Synthetic Methodology ”:Taking Preparation of

Ethyl Benzoate as an Example

CHEN Miao #CHEN Yong-Jia #DING Er-Dong #DAI Chang-Hang #FANG Fan #GAO Kai-Min #HUO Jia-Tong #JIANG Xiao-Yu #JIANG Zi-Yuan #LI Yang #LI Zhi-Hao #LI Wei-Xingyue #LIU Zi-Chen #TANG Tian-Hua #WANG Chang #ZHANG Shu-Kun #

ZHENG Xin-Ping #ZONG Jia-Rui #LIU Shuo LI Yu-Xin HAN Jie *

(National Demonstration Center for Experimental Chemistry Education,College of Chemistry,Nankai University,

Tianjin 300071,P .R.China )

Abstract:Synthetic methodology has been introduced to organic chemistry laboratory course by taking the preparation of ethyl benzoate as an example.The experiments for each student were carried out by drawing lots,and the reaction conditions such as heating sources (electricity or microwave power),solvents (toluene or cyclohexane)and reaction time were investigated by the undergraduate students.Additionally,the critical review of chemical literatures was added into the teaching and the experiment results were discussed in order to improve the innovative thinking and scientific research ability of the undergraduate students.

Key Words:Synthetic methodology;Innovative ability;Teaching reform

有机合成方法学是研究有机新反应和探索最佳有机反应条件的基本手段，是理解有机反应机理及23