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血清脂蛋白a、胱抑素C和尿酸的联合检测在高血压并发脑梗死患者中的诊断价值

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血清脂蛋白a、胱抑素C和尿酸的联合检测在高血压并发脑梗死患者中的诊断价值

作者:吕燕海丁友辉曾国志

来源:《中国当代医药》2017年第09期

[摘要]目的探讨联合检测血清脂蛋白a[Lp(a)]、胱抑素C(Cys-C)及尿酸(UA)在高血压并发脑梗死中的诊断价值。方法选择2014年4月~2015年10月我院64例高血压并发脑梗死患者作为观察组,选择我院同期72例单纯高血压患者作为对照组,分别采用胶乳增强免疫透射比浊法和重组尿酸氧化法测定两组患者的Lp(a)、Cys-C及UA水平,比较两组Lp (a)、Cys-C及UA的表达水平,并评估Lp(a)、Cys-C及UA联合检测在高血压并发脑梗死中的诊断价值。结果观察组Lp(a)、Cys-C及UA分别为(379.64±60.28)mg/L、

(1.03±0.24)mg/L及(515.60±64.42)μmol/L,均显著高于对照组的(302.35±47.91)mg/L、(0.86±0.07)mg/L及(427.83±47.65)μmol/L,差异均有统计学意义(P

[关键词]高血压;脑梗死;脂蛋白(a);胱抑素C;尿酸

[中图分类号] R446.1 [文献标识码] A [文章编号] 1674-4721(2017)03(c)-0128-03

[Abstract] Objective To investigate the effectiveness of combination of detection of serum lipoprotein a[Lp(a)],cystatin C (Cys-C) and uric acid (UA) in the diagnosis of hypertension patients complicated with cerebral infarction.Methods Altogether 64 patients with hypertension complicated with cerebral infarction who were treated in our hospital from April 2014 to October 2015 were selected as observation group;while,72 patients with hypertension who were treated in the hospital at the same period were selected as control group.Lp(a),Cys-C and UA of the two groups were measured by using latex-enhanced immunoturbidimetric assay and recombinant uric acid oxidation;and the expression levels of Lp(a),Cys-C and UA were compared between the two groups;the value of combination of detection of Lp(a),Cys-C and UA in the diagnosis of hypertension patients complicated with cerebral infarction was evaluated.Results Lp(a),Cys-C and UA of observation group were (379.64±60.28) mg/L,(1.03±0.24) mg/L and

(515.60±64.42)μmol/L,respectively,significantly higher than control group

[(302.35±47.91) mg/L,(0.86±0.07) mg/L and (427.83±47.65)μmol/L],with statistically significant difference (P

[Key words] Hypertension;Cerebral infarction;Lp(a);Cys-C;UA

脑梗死是高血压常见并发症,致残率和致死率高,严重威胁患者生命健康和生活质量,对脑梗死的早期诊断直接影响患者预后[1]。目前研究认为脂蛋白a[Lp(a)]和尿酸(UA)与动脉粥样硬化的形成密切相关,而胱抑素C(Cys-C)长期以来被认为是评价肾功能的重要标志

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