HTH-01-015_1613724-42-7_DataSheet_MedChemExpress

Product Name:

HTH-01-015CAS No.:

1613724-42-7Cat. No.:

HY-12334MWt:

468.55Formula:

C26H28N8O Purity :>98%

Solubility:Mechanisms:

Biological Activity:

References:

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/3016010398.html,

[1]. Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-

tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457(1):215-25.HTH-01-015 is a potent and selective inhibitor of NUAK1 with IC50 of 100 nM, does not significantly inhibit

NUAK2 (IC50 of >10 μM).

IC50 value: 100 nM [1]

Target: NUAK1HTH-01-015 did not markedly suppress the activity of any of the other 139 protein kinases evaluated.Treatment of cells with 10 μM HTH-01-015, the NUAK1 isoform selective inhibitor, only led to a partial

inhibition of MYPT1 phosphorylation. In HEK-293 cells expressing wild-type NUAK1, concentrations of 3–10μM WZ4003 or HTH-01-015 markedly suppressed phosphorylation of MYPT1.

Pathways:PI3K/Akt/mTOR; Target:AMPK Product Data Sheet

DMSO

18 W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A

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