Quinpirole-Hydrochloride-DataSheet-MedChemExpress

Quinpirole Hydrochloride

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

10 mg

1 mM 5 mM 10 mM

Mass

Volume

Concentration

PROTOCOL

Animal Administration [1]Rat[1]

36 male Long-Evans rats are injected daily for 12 days with either saline or Quinpirole (Hydrochloride) (quinpirole HCl: 0.5 mg/kg, s.c., n=18/condition), and placed immediately in Omnitech activity monitors (60×60×40 cm) for 90 min. On the final test day, half the rats in each chronic condition received saline and half Quinpirole (n=9/group). The four groups therefore represented saline controls (SS), acute Quinpirole (SQ), sensitized Quinpirole (no drug)(QS) and sensitized Quinpirole (drug) (QQ). 30 min after the final injection, each rat is removed from the activity monitors to a nearby room and killed immediately by decapitation. This time point is chosen to dissociate the behavioural effects of quinpirole between groups, since acute quinpirole produces inhibition of activity at this time, while chronic quinpirole is associated with pronounced hyperlocomotion at 30 min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

REFERENCES

[1]. Sullivan RM, et al. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience. 1998 Apr;83(3):781-9.

Caution: Product has not been fully validated for medical applications. For research use only.

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