多孔磷酸钙生物材料的制备及表征

多孔磷酸钙生物材料的制备及表征

【摘要】目的制备适合新骨长入的孔隙率、孔隙尺寸和结构的多孔磷酸钙组

织工程支架材料。方法通过湿法共沉淀法合成羟基磷灰石(HA) /磷酸三钙(TCP)双相粉末,釆用有机泡沫浸浆法和适当的致孔剂,分别制备多孔磷酸钙陶瓷和多孔磷酸钙骨水泥。采用扫描电镜观测试样的孔隙结构,测量其孔隙率,利用X射线衍射分析其相成分。结果多孔磷酸钙陶瓷和磷酸钙骨水泥的孔隙率分别为72%和67%;孔隙尺寸分布在200M m和280M m左右;孔壁上分别存在大量孔径为数微米至数十微米的微孔;X射线衍射结果证明多孔磷酸钙陶瓷的组成包括HA和p TCP,骨水泥的成分为HA, a TCP and p TCP。结论试验制备的多孔磷酸钙生物材料具有适合新骨长入的孔隙直径、孔隙率和良好的生物相容性。

【关键词】多孔磷酸钙陶瓷;骨水泥;微孔;生物相容性

Preparation and Characteration of Porous Calcium Phosphate Bioactive Material for Bone Tissue Engineering

[Abstract] Objective To prepare the adaptive porous calcium phosphate bioactive material. Methods The hydroxyapatite/tricalcium phosphate biphasic powder was synthesized by the wet

co precipitation method. Then polymer sponge immersion method and appropriate progeny were used to prepare porous calcium phosphate (CaP) . The morphology and structure of CaP ceramics and CPC were observed by scanning electronic microscopy (SEM). Their phase compos i tion were analyzed by X ray di iTmct.ion(XRD). Results The porosities of CaP ceramics and CPC were 72% and 67% respectively. Their pore sizes were 200 to 280 |J m. The results of XRD showed that CaP ceramics composed of HA and P Tcp, CPC composed o「IIA, p TCP. Conclusion The preparation by the experiment has appropriate pore size and porosity and excellent biocompatibility which are suitable to the bone in growth.

【Key words】 porous calcium phosphate (CaP) ceramics; cement; micro pore; biocompatihi1ity

i前言

磷酸钙生物材料由于具有与自然骨组织相似的无机成分,因此表现出优良的生物相容性,植入体内后能够与骨组织形成骨键合,被称为生物或材料,并已经成功地被应用于临床骨缺损的修复和填充[1]。但是,临床常常会遇到病理情况下的骨缺损,如骨质疏松导致的骨缺损,患者的骨密度低,骨修复能力差;或者大体积的骨缺损。由于无机的磷酸钙生物材料缺乏生长因子、蛋白质

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