CGK733_905973-89-9_DataSheet_MedChemExpress

Product Name:

CGK733CAS No.:

905973-89-9Cat. No.:

HY-15520MWt:

555.84Formula:

C23H18Cl3FN4O3S Purity :>98%

Solubility:Mechanisms:Biological Activity:

References:

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/7b11521059.html,

[1]. Alao JP, Sunnerhagen P. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels

and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51.[2]. Wang H, Zuo B, Wang H, Ren L, CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Biochem Biophys Res

Commun. 2012 May 25;422(1):103-8. CGK 733 is a small molecule inhibitor reportedly targeting the kinase activities of ATM and ATR.

IC50 Value:

Target: ATM/ATR in vitro: Culture of MCF-7 breast cancer cells with 10 μM CGK733 induced a detectable decline of cyclin D1levels within 2 h of exposure, and this effect was maximal between 4 and 6 h after exposure, CGK733

induced the loss of cyclin D1 expression at concentrations as low as 5 μM and this activity was maximal at 10 to 20 μM The CGK733 induced attenuation of cyclin D1 levels was inhibited by the 26S proteasome inhibitor MG132 but not the GSK3β inhibitor lithium chloride (LiCl) in MCF-7 and T47D cells [1]. CGK733significantly enhanced taxol-induced cytotoxicity in HBV-positive HepG2.2.15 cells. The mechanism lies in CGK733 triggers the formation of multinucleated cells thus promotes the premature mitotic exit of taxol-induced mitotic-damaged cel... Pathways:Cell Cycle/DNA Damage; Target:ATM

Pathways:PI3K/Akt/mTOR ; Target:ATM

Pathways:Cell Cycle/DNA Damage; Target:ATR Product Data Sheet

DMSO

11 D e e r P a r k D r i v e , S u i t e 102D M o n m o u t h J u n c t i o n , N J 08852,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m