Varlitinib (ARRY334543)_ErbB抑制剂_845272-21-1_Apexbio

产品名: Varlitinib (ARRY334543)修订日期: 6/30/2016产品说明书

化学性质

产品名:

Varlitinib (ARRY334543) Cas No.:

845272-21-1 分子量:

466.94 分子式:

C22H19ClN6O2S 别名:

ARRY-334543; ARRY 334543 化学名:

4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methy l-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine SMILES:

CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=N C=CS5)Cl 溶解性:

>23.4mg/mL in DMSO 储存条件:

Store at -20°C 一般建议: For obtaining a higher solubility , please warm the tube at 37°C

and shake it in the ultrasonic bath for a while.Stock solution can be

stored below -20°C for several months.

运输条件:

Evaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

生物活性

靶点 :

JAK/STAT Signaling 信号通路:

EGFR 产品描述:

Varlitinib is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in

inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and

cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and

Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.

参考文献:

特别声明

产品仅用于研究，

不针对患者销售，望谅解。

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