ChihYangHuang-english
BIOGRAPHICAL SKETCH
NAME
Chih-Yang Huang POSITION TITLE
Director and Professor of Institute of Basic Medical Science
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
National Yang-Ming University, Taipe i M.S. 1989 Endocrinology University of Illinois, Urbana, USA M.S. 1995 Breast Cancer University of Illinois, Urbana, USA Ph.D. 1998 Molecular Cardiology
Current Positions
Director, Institute of Basic Medical Science;
Director, Core Lab in the College of Medical Science and Chinese Medical Science;
Professor, Graduate Institute of Chinese Medical Science, China Medical University;
Adjunct Professor, Institute of Molecular Biology, National Chung Cheng University;
Adjunct Professor,Institute of Nutritional Health, Asia University.
Adjunct Professor, Institute of Nutritional Science, Hun-Kun University.
Employment
1987-1989 National Yang-Ming University, Physiology Part Time Teaching Assistant
1989-1991 Taiwan Army 39th officer (醫勤官兼333師營站主任)
1992-1996&1996-1998 U niversity of Illinois, Urbana, USA; Teaching Assistant & Research Assistant Institute of Biochemistry, Chung Shan Medical University, 1999.8-2002.8 Full-time assistant Professor. Institute of Biochemistry, Chung Shan Medical University, 2002.8-2005.10 associate professor.
Institute of Molecular Biology, National Chung Cheng University, 2000-2002 part-time assistant Professor, 2002-2005 associate professor.
Chung Shan Medical University, Innovation and Business Incubation Center, director, 2005.8-2006.8.
Honors
1989 National Yang-Ming University, Taipei Master I-Shen-Zo research award
19th & 21 th Joint Conference of BioMedicial Science, Biochemistry Poster award
213th Joint Conference of BioMedicial Science, Physiology Poster award
2006 (for 3 years) Distinguished Investigators Award, China Medical University, Taiwan
2006-2008 Li-Chen Biotechnique incorporation,Consultant, Taichung
2006-2009, The Chinese Journal of Physiology (SCI), invited author
2007-2008, Adaptive Medicine Society, Organizing Board Member
2008 Outstanding Alumni Award of Nutritional Science Department, Fu-Jen University, Taiwan
2009-present Sun-Ten Tong Chinese Medical Hospital, Consulant, Taichung County
2009 Mar 23-25, 24th Joint Conference of BioMedicial Science, Taipei: Chair of Physiology seminar section and invited speaker.
2009 Aug 2-5, International Conference of Adaptive Medicine Society, Taipei: organizing board member and invited speaker.
Editorial Board
2009-present, The Chinese Journal of Physiology (SCI)
2009-present, The Mid-Taiwan Journal of Medicine (Associate Editor)
Reviewer (since 2004)
Journal reviewer:International J. of Cardiology, Chinese J. of Physiol., Molecular Cellular Biochemistry, Journal of molecular and cellular cardiology, Clinica Chima Acta, Pharmacology research, Journal of Cardiovascular Pharmacology, Clinical Biochemistry, Apoptosis, Acta Pharmacologica Sinica. J.
of Endocrinology, J. of Molecular Medicine.
Project reviewer: P hilip Morris external Research Program, Tzu Chi human clinical trail project, Taichung Veterans General Hospital project, NSC project
Peer-reviewed publications (since 2004)
1.Chung-Jung Liu,Jeng-Fan Lo, Chia-Hua Kuo, Chun-Hsien Chu,Li-Ming Chen, Fuu-Jen Tsai, Chang-Hai
Tsai, Bor-Show Tzang*, Wei-Wen Kuo* and Chih-Yang Huang*. Akt Mediates 17β-Estradiol and/or Estrogen Receptor Inhibition of LPS-Induced Tumor Necrosis Factor-αExpression and Myocardial Cell Apoptosis by Suppressing the JNK1/2 and NF k B Pathway. 2009,J. of Cellular and Molecular Medicine, in press Impact Factor:6.82] (3x5x6.82=+102) (Correspondence Author)
2.Chun-Hsien Chu, Bor-Show Tzang, Li-Ming Chen, Chung-Jung Liu, Fuu-Jen Tsai Chang-Hai Tsai,
James A. Lin, Da-Tian Bau*, Chun-Hsu Yao*, Chih-Yang Huang4*. Specific Activated IGF2R Induces Mitochondria-dependent Apoptosis through Gαq and Downstream Calcineurin Signaling in Myocardial Cells.
Endocrinology.2009in press. [Epub ahead of print]SCI SCI Ranking:15%(Endocrinology); Impact Factor:5.32] (3x5.3x5=+80) (Correspondence Author)
3.Ray-Jade Chen, Wei-Wen Kuo, Mu-Hsin Chang, Chao-Hung Lai, Jin-Ming Hwang,Wu-Hsien Kuo,
Fuu-Jen Tsai, Chang-Hai Tsai, Li-Mien Chen*, Chih-Yang Huang*, Chun-Hsien Chu* Leu27IGF-II plays opposite role with IGF-I to induce H9c2 cardiomyoblast cell apoptosis via Gαq signaling. J Mol Endocrinol.2009in press. [Epub ahead of print]SCI SCI Ranking:35%(Endocrinology); Impact Factor:2.92] (3x4x5=+60) (Co-correspondence Author)
4.Chih-Yang Huang, Li-Chiu Yang, Kuan-Yu Liu, Pao-Hsin Liao Liao, Janet Ing-Yuh Chou, Ming-Yung
Chou, Wei-Wen Lin and Jaw-Ji Yang RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK. Journal of Biomedical Science 2009in press.SCI (First Author) (3x5x3.5(NSC加重計分)=+52.5)
5.Yi-Chang Cheng,Li-Mien Chen, Mu-Hsin Chang, Wei-Kung, Chen, Fuu-Jen Tsai, Chang-Hai Tsai,
Yi-Chang Cheng, Wei-Wen Kuo* and Chih-Yang Huang*,Chung-Jung Liu* Lipopolysaccharide-Upregulated uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 Cardiomyoblast Cells. Mol Cell Biochem. 2009in press.
[60~80%,2005,SCI,ImpactFactor:1.681] *(co-Correspondence Author) (3x5x2= +30)
6.Yi-Chang Cheng, Wei-Wen Kuo, Hsi-Chin Wu, Tung-Yuan Lai, Jin-Ming Hwang, Wen-Hung Wang,
Fuu-Jen Tsai, Jaw-Ji Yang*, Chih-Yang Huang*, Chun-Hsien Chu* ZAK induces MMP-2 activity via JNK/ p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells. Mol Cell Biochem.2009in press.
[60~80%,2005,SCI,ImpactFactor:1.681] *(co-Correspondence Author) (3x5x2= +30)
7.Ming-Chin Lu, Tung-Yuan Lai, Jin-Ming Hwang, Hsien-Te Chen3 Sheng-Huang Chang, Fuu-Jen Tsai,
Hwai-Lee Wang, Chien-Chung Lin*, Wei-Wen Kuo*, Chih-Yang Huang* Proliferation- and migration- enhancing effects of Ginseng and Ginsenoside Rg1 through IGF-I- and FGF-2-signaling pathways on RSC96 Schwann Cells (Cell Biochemistry and Function,2009,in press(Correspondence Author) [60-80%, 2005 SCI Impact Factor:1.64] (3x5x2= +30) (Correspondence Author)
8.Chi-Chang Huang, Tien-Jen Lin, Yi-Fa Lu, Chun-Chieh Chen, Chih-Yang Huang*, Wan-Teng Lin*
Protective Effects of L-Arginine Supplementation Against Exhaustive Exercise-Induced Oxidative Stress in Young Rat Tissue (Chinese Journal of Physiology,2009, in press*(Co-Correspondence Author) NSC special x1.5, Impact Factor: 0.803] (3x5x1.5(NSC加重計分)=+22.5)
9.Eric https://www.wendangku.net/doc/7613475745.html,i, Yi-Jiun Weng, Wei-Wen Kuo, Li-Mien Chen, Yun-Ting Chung, Yueh-Min Lin,
Fuu-Jen Tsai, Tung-Yuan Lai*, Chih-Yang Huang*,Yu-Lan Yeh* Tao-He-Cheng-Qi-Tang ameliorated the acute liver injury induced by carbon tetrachloride (CCl4) in rats (Chinese Journal of Physiology,2009, in press*(Co-Correspondence Author) NSC special x1.5, Impact Factor: 0.803] (3x5x1.5(NSC加重計分)=+22.5)
10.Shin-Da Lee, Wei-Wen Kuo, Da-Tian Bau, Fu-Yang Ko, Fong-Li Wu, Chia-Hua Kuo, Jin-Ming Hwang,
Shyi-Gang P. Wang, Min-Chi Lu*, Chih-Yang Huang*. The coexistence of intermittent hypoxia and obesity additively increase cardiac apoptosis (Journal of Applied Physiology,2008, 104(4):1144-53 ) [ 11.Chiou, S.H.,C.C. Yu, C.Y. Huang, S.C. Lin,C.J. Liu, T.H. Tsai, S.H. Chou, C.S. Chien, H.H. Ku, J.F. Lo. Positive Correlations of Oct-4 and Nanog in Oral Cancer Stem-Like Cells and High Grade Oral Squamous Cell Carcinoma. Clinical Cancer Research. 2008.14: 4085-4095.SCI Impact Factor:6.32] (3x1x6.32=+18) 12.Tseng HC, Tsai MH, Chiu CF, Wang CH, Chang NW, Huang CY, Tsai CW, Liang SY, Wang CL, Bau DT Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan. Anticancer Res. 2008; 28(3A):1687-91. 13.Tsai-Ching Hsu, Yi-Chen Chen, Wen-Xian Lai, Szu-Yi Chiang, Chih-Yang Huang*, Bor-Show Tzang*. Beneficial effects of treatment with cystamine on brain in NZB/W F1 mice.European Journal of Pharmacology2008,591:307-314SCI.[20%~40%, 2005 SCI](3x3x5=+45)(Co-correspondence Author) 14.Tsai-Ching Hsu, Szu-Yi Chiang, Jen-Huang Wu, Chun-Chou Tsai, Chih-Yang Huang,Yi-Chen Chen, Bor-Show Tzang. Treatment with Taurine Attenuates Hepatic Apoptosis in NZB/W F1 Mice Fed with a High-Cholesterol Diet. J. Agric. Food Chem. September 25, 200856(20):9685-9691. [Epub ahead of print] SCI(3x5x5=+75) (Co-correspondence Author) 15.Yi-Chang Cheng, Wei-Wen Kuo, Chieh-Hsi Wu, Wen-Tong Shu, Chia-Hua Kuo, Jin-Ming Hwang, Hsi-Hsien Hsu, Li-Ming Chen#, Chih-Yang Huang #, Shin-Da Lee PhD# Iron status and cardiovascular risk factors in patients with hemodialysis versus patients with ischemic heart disease. Nephrology. 2008 in press*(Co-correspondence Author) [60%~80%, 2007 SCI Ranking: 41/55 (Urology &nephrology); Impactfactor:1.241](CJA:3x2x5=+30) 16.Shin-Da Lee, Wei-Wen Kuo, Ying-Jui Ho, Ann-Chi Lin, Chang-Hai Tsai, Hsueh Fang Wang, Chia-Hua Kuo, Ai-Lun Yang*, Chih-Yang Huang*,Jin-Ming Hwang*Cardiac Fas-dependent and mitochondria-dependent apoptosis in ovariectomized rat. [32%:20%~40%, 2006 SCI Ranking:19/59 (obsteric-gynecol); Impact Factor:1.947] Maturitas. 200861(3):268-277*(Co-correspondence Author) (3x5x4= +60) 17.Chun-Hsien Chu*, Chih-Yang Huang*, Ming-Chin Lu, James A. Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Yih Chu, Wu-Hsien Kuo, Li-Mien Chen1, Ling-Yun Chen IGF-II Synergistically Enhances AG1024-induced H9c2 Cardiomyoblast Cell Apoptosis via the Interaction of IGF2R with Gα Proteins and Its Downstream PKA and PLC-β Modulators. (Chinese Journal of Physiology, 2008, in press) *(Co-First Author) (3x5x1.5(NSC加重計分)=+22.5) 18.Chung-Jung Liu,Yi-Chang Cheng,Kung-Wei Lee,Hsi-Hsien Hsu,Chun-Hsien Chu, Fuu-Jen Tsai, Chang-Hai Tsai, Chia-Yih Chu, Jer-Yuh Liu, Wei-Wen Kuo and Chih-Yang Huang* Lipopolysaccharide induces cellular hypertrophy through calcineurin/NFAT-3 signaling pathway in H9c2 myocardiac cells. Mol Cell Biochem.2008;313(1-2):167-78.[60~80%,2005,SCI,ImpactFactor:1.681] *(Correspondence Author) (3x5x2= +30) 19.Chang MH, Kuo WW, Chen RJ, Lu MC, Tsai FJ, Kuo WH, Chen LY, Wu WJ, Huang CY*, Chu CH. IGF-II/mannose 6-phosphate receptor activation induces metalloproteinase-9 matrix activity and increases plasminogen activator expression in H9c2 cardiomyoblast cells.J Mol Endocrinol.2008 41(2):65-74 SCI Ranking:33%(Endocrinology); Impact Factor:2.96] (3x4x5=+60) (Co-correspondence Author) 20.Wen-Yuan Lin, Tai-Yuan Chiu, Long-Teng Lee, Cheng-Chieh Lin, Chih-Yang Huang and Kuo-Chin Huang. Betel nut chewing is associated with increased risk of cardiovascular disease and all-cause mortality in Taiwanese men. American Journal of Clinical Nutrition,2008,87(5), 1204-1211. SCI 21.Chun-Hsien Chu,Bor-Show Tzang, Li-Mien Chen, Chia-Hua Kuo, Yi-Chang Cheng, Ling-Yun Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Wei-Wen Kuo*, Chih-Yang Huang*IGF-II receptor signaling induced cell hypertrophy and ANP/BNP expression via Gαq interaction and PKCα/ CaMKII activation in the H9c2 cardiomyoblast cells. (Journal of Endocrinology,2008, 197(2),381-390) [ 2005:SCI Ranking:33%(Endocrinology); Impact Factor:3.0] (3x4x5=+60) (Correspondence Author) 22.Tsai, J.H., Liu, J.Y., Wu, T.T., Ho, P.C., Huang, C.Y., Shyu, J.C., Hsieh, Y.S., Tsai, C.C., and Liu Y.C. Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. Journal of Viral Hepatitis, in press,2008.SCI 23.Wei-Wen Kuo, Chung-Jung Liu, Chun-Hsien Chu, Yi-Jiun Weng, May-Hua Jen, Ming-Chin Lu, Fuu-Jen Tsai, Chang-Hai Tsai and Chih-Yang Huang* A Phonex Arising From Fire: New Application of Old Traditional herbs, Chapter 6: Traditional Chinese Medicine on Protection of Heart Function and Cardiovascular System. Research Signpost, 2008, (Correspondence Author) 24.Te-Chi Liu, Yung-Yang Liu, Shin-Dd Lee, Chih-Yang Huang, Kuei-Yu Chien, I-Shiung Cheng, Chih-Yuan Lin, Chia-Hua Kuo, Effects of short-term detraining on measures of obesity and glucose tolerance in elite athletes. Journal of Sports Sciences, 2008; 26(9): 919-925 SCI 25.Tsai-Ching Hsu,Ji-Qiang Gao,Ko-Hsiu Lu,Chang-Hai Tsai,Chih-Yang Huang*, Bor-Show Tzang*. Japanese Encephalitis Virus Envelope Protein Mitigates TNF-α mRNA Expression in RAW264.7Cells Inflammation, 2008,31(2),133-140 SCI (Co-correspondence Author) 26.Hsu TC, Huang CY, Chiang SY, Lai WX, Tsai CH, Tzang BS. Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice. Eur J Pharmacol.2008,579(1-3):382-389, SCI. [20%~40%, 2005 SCI] (3x3x4=+36) 27.Hsi-Chin Wu, Yu-Lan Yeh, Wei-Wen Kuo, Shu-Kuei Huang, Wu-Hsien Kuo, Dennis Jine-Yuan Hsieh, Ching-Lin Wu, Chang-Hai Tsai, Shin-Da Lee*, Chih-Yang Huang*. P38 mitogen-activated protein kinase pathways are involved in the hypertrophy and apoptosis of cardiomyocytes induced by Porphyromonas gingivalis conditioned medium (Cell Biochemistry and Function,2008, 26(2):246-255) (Correspondence Author)[60-80%, 2005 SCI Impact Factor:1.64] (3x5x2= +30) (Correspondence Author) 28.Mei-Kuei Wu, Chih-Yang Huang, Ying Jay Liou, Chin-Kun Wang, Shin-Da Lee. Glucose-insulin homeostasis, lipid profiles and GH-IGF-IGFBP axis in clozapine-treated schizophrenic obesity versus non-psychiatric obesity. (International Journal of Obesity,2008, 32(3):436-42) [Top 10%, 2006 SCI Ranking: 4/55(Nutrition&Dietetics); Impact Factor: 4.055](CJA:3x3x5= +45) 29.Yueh-Min Lin, Shu-Kuei Huang, Hsueh Fang Wang, Li-Mien Chen, Fuu-Jen Tsai, Hsi-Hsien Hsu, Chia-Hua Kuo, Shyi-Gang P. Wang, Chih-Yang Huang*,Shin-Da Lee*. Short-Term versus Long-Term Intermittent Hypobaric Hypoxia on Cardiac fibrosis and Fas-Death-Receptor Dependent Apoptotic Pathway in Rat Hearts (Chinese Journal of Physiology,2008, 51(5):308-316 *(Co-Correspondence Author) NSC special x1.5, 2007 SCI Ranking: 66/78 (physiology); Impact Factor: 0.803] (3x5x1.5(NSC加重計分)=+22.5) 30.Chung-Jung Liu, Jin-Ming Hwang, Trang-Tiau Wu, Yi-Hsien Hsieh, Cheng-Chung Wu, Yih-Shou Hsieh, Chang-Hai Tsai, Hsi-Chin Wu, Chih-Yang Huang*,and Jer-Yuh Liu*. Anion Exchanger Inhibitor DIDS Induces Human Higher Maligant Hepatoccellular Carcinoma HA22T Cell Apoptosis. Moelcular and cellular Biochemistry.2008,308(1-2):117-125SCI. [60~80%, 2005 SCI Impact Factor:1.681] *(Co-Correspondence Author) (3x5x1.5= +22.5) 31.Hui-Man Cheng, Chien-Yun Hsiang, Guang-Wei Chen, Shih-Lu Wu, Jaw-Chyun Chen, Chih-Yang Huang, Da-Tian Bau, Tin-Yun Ho. LPS-Induced Interleukin-1α and TNF-αProduction is inhibited by Menthone through NF-kB signaling Pathway in HaCat Cells.Chinese Journal of Physiology, 2008.51(4):1-7. SCI [2005 SCI Impact Fact: 0.73] (3x0.5x2(NSC加重計分)=+3) 32.Jin-Ming Hwang, Yi-Jiun Weng, Yueh-Min Lin,Da-Tian Bau, Fu-Yang Ko, Fuu-Jen Tsai, Chieh-Hsi Wu, Pei-Cheng Lin*,Chih-Yang Huang*, Wei-Wen Kuo*Hypoxia-induced compensatory effect as related to Shh and HIF-1α in ischemia embryo rat heart. Moelcular and cellular Biochemistry.2008, 311(1-2):179-187 SCI. [60~80%, 2005 SCI Impact Factor:1.681] *(Co-Correspondence Author) (3x5x1.5= +22.5) -------------------------------------------------------------------------------------------------------------- 33.Tsai-Ching Hsu, Szu-Yi Chiang,Chih-Yang Huang,Gregory J Tsay,Chiao-Wen Yang,Chien-Ning Huang,Bor-Show Tzang. Beneficial effects of treatment with transglutaminases inhibitor cystamine on macrophage response in NZB/W F1 mice. (Experimental Biology and Medicine, 2007, 232:195-203) [20%~40%, 2005 SCI] (3x1x4=+12) 34.Hsu TC, Huang CY, Chiang SY, Lai WX, Tsai CH, Tzang BS. Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice. Eur J Pharmacol.2007,579:382-389, SCI. 35.Lu MC, Bor-Show Tzang, Kuo WW, Wu FL, Chen SH, Liu JY, Hwang JM, Lin JA, Chen JS, Huang CY*, Lee SD*. More activated cardiac mitochondrial dependent apoptotic pathway in obese Zucker rat. (Obesity ,2007;15;2634-2642)----[ 36.Shin-Da Lee, Bor-Show Tzang, Wei-Wen Kuo, Yueh-Min Lin, Szu-Hua Chen, Jwo-Sheng Chen, Fuu-Jen Tsai, Fong-Li Wu, Min-Jin Lu*, Chih-Yang Huang*. Fas receptor-dependent apoptotic pathway in obese Zucker rats' hearts. Obesity2007;15(10):2047-2015,SCI(Obesity, submitted 2006.11.12) ----[ 3.972]*(Correspondence Author) (3x5x5= +75) 37.Yang AL, Lo MJ, Ting H, Chen JS, Huang CY*, Lee SD*. GABA(A) and GABA(B) Receptors Mediated Modulation of Ventilation and Peak Aerobic Exercise Capacity in Obese Zucker Rats. (Journal of Applied Physiology,2007, 102(1):350-7. [ Impact Factor:3.037] (Co- correspondence author)(3x5x5=+75) 38.Lee SD, Kuo WW, Lin JA, Chu YF, Wang CK, Yeh YL, Chang MH, Wang SG, Liu JY, Huang CY. Effects of long-term intermittent hypoxia on Mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts.International Journal of Cardiology, 2007,116(3):348-56, SCI [40%~50%, 2005 SCI Ranking:32/72(Cardiovascular System); Impact Factor:1.765] (corresponding author). (3x5x3=+45) 39.Hsieh, Y.H., Wu, T.T.,Huang, C.Y.,Hsieh, Y.S., Hwang, J.M., and Liu, J.Y. p38 MAPK Pathway Is Involved in Protein Kinase Cα-Regulated Invasion in Human Hepatocellular Carcinoma Cells. Cancer Research, 2007; 67(9):4320-4327 [Impact Factor: 7.67] (3x1x7.67= +23) 40.Jong GP, Wang YF, Tsai FJ, Chang HJ, Wu CL, Liu RH, Wu CC, Hsieh JY,Huang CY*,Lee SD*. Immunoglobulin E and matrix metalloproteinase-9 in patients with different stages of coronary artery diseases. Chinese Journal of Physiology, 2007.50(6):277-282. SCI [2005 SCI Impact Fact: 0.463] *(Co-Correspondence Author) (3x5x2(NSC加重計分)=+30) 41.Li-Mien Chen, Wei-Wen Kuo, Jaw-Ji Yang, Shyi-Gang P. Wang, Yu-Lan Yeh, Fuu-Jen Tsai, Ying-Jui Ho, Mu-Hsin Chang, Chih-Yang Huang*, Shin-Da Lee*. Eccentric Cardiac Hypertrophy was Induced by Long-term Intermittent Hypoxia. (Experimental Physiology, 2007;92(2):409-416) [2005: SCI Ranking: 40/75(Physiology), Impact Factor:2.054]*(Co-Correspondence Author)(3x1.5 x5=+22.5) 42.Mu-Hsin Chang, Wei-Wen Kuo, Ping-Chun Li, Ding-Yu Lin, Shin-Da Lee, Fuu-Jen Tsai, Gwo-Ping Jong, Yueh-Min Lin , Chih-Yang Huang*. Wen-Jun Wu*. Down regulation of IGF-I and IGF-IR gene expression in cardiac tissue of infants with isolated ventricular septal defect. Clinica Chimica Acta. 2007, 232(2):195-203, SCI [20%~40%, 2005 SCI Ranking:5/23 (Medicine Lab); Impact Factor: 2.129] (3x4 x5=+60).*(Co-Corespondence Author) 43.Wu MK, Bai YM, Wang CK, Huang CY, Lee SD*. Outcomes of obese, clozapine-treated inpatients with schizophrenia placed on a six-month diet and physical activity program. Psychiatr Service. 2007;58(4):544-50. )--------[24%, 2006 SCI Ranking: 23/98 (Public, environmental & occupational health); Impact Factor:2.43] (3x0.5x5= +7.5) 44.Hsieh, Y.H., Wu, T.T., Huang, C.Y., Hsieh, Y.S., and Liu, J.Y.Suppression the Tumorigenicity of Human Hepatocellular Carcinoma Cells by Antisense Oligonucleotide MZF-1. Chinese Journal of Physiology, 2007;50(1):9-15. SCI[2005 SCI Impact Fact: 0.463] (3x1x2(NSC加重計分)=+6) 45.Da-Tian Bau, Ming-Hsui Tsai, Cheng-Chun Lee, Chih-Yang Huang, Hsien-Chang Tseng, Yen-Li, Lo, Yuhsin Tsai, Fuu-Jen Tsai. Study of Association between Polymorphisms of Nucleotide Excision Repair Genes and Oral Cancer Risk in Taiwan: Evidence for Effect Modification by Smoking Habit. Chinese Journal of Physiology, 2007;50(6):1-7. SCI [2005 SCI Impact Fact: 0.463] (3x0.5x2(NSC加重計分)=+3) 46.Trang-Tiau Wu, Yi-Hsien Hsieh, Cheng-Chung Wu, Yih-Shou Hsieh,Chih-Yang Huang, Jer-Yuh Liu. Overexpression of protein kinase Cα mRNA in human hepatocellular carcinoma: A potential marker of disease prognosis.Clinica Chimica Acta.2007, 382(1-2):54-58, SCI [20%~40%, 2005 SCI Ranking:5/23 (Medicine Lab); Impact Factor: 2.129] (3x0.5 x4=+6). -------------------------------------------------------------------------------------------------------------- 47.Wei-Wen Kuo, Chung-Jung Liu, Li-Ming Chen, Chu-Hsien Chu, Jer-Yuh Liu, Min-Chi Lu, James A Lin, Shin-Da Lee, Chih-Yang Huang. Cardiomyocyte apoptosis induced by insulin-like growth factor-I resistance is insulin-like growth factor-II dependent and synergistically enhanced by angiotensin II. Apoptosis,2006,Jul;11(7):1075-89. SCI [NSC 91-2320-B-040-019] [20%, 2005 SCI Ranking:53/261 (Biochemistry & Molecular Biology; Impact Factor: 4.497] (corresponding author) (3x4x5=+60) 48.Shin-Da Lee, Chun-Hsine Chu, Erh-Jung Huang, Chung-Jung Liu, James A Lin, Jer-Yuh Liu, Min-Chi Lu, His-Shine Hsu, Wei-Wen Kuo, Chih-Yang Huang. Role of insulin-like growth factor-II in cardiomyoblast apotosis and in hypertensive rat heart with abdominal aorta ligation. American Journal of Physiology-Endocrinology and Metabolism,2006,Aug;291(2):E306-14. SCI[NSC 89-2311-B-040-006].[Top 10%, 2005 SCI Ranking:6/75(Physiology); Impact Factor:4.456] (corresponding author) (3x5x5=+75) 49.Shin-Da Lee, Wei-Wen Kuo, Yu-Chao Chang, Sheng-Huang Chang, Hsien-Ping Huang, Jia-Ping Wu, Erh-Jung Huang, Chung-Jung Liu, Jer-Yuh Liu, Ter-Hsin Chen, Chih-Yang Huang.Porphyromonas gingivalis-induced MMP-9 activity and cardiomyoblast hypertrophy via different pathways of H9c2 cardiomyoblast cells.J of Periodonology . 2006, Apr;77(4):684-91, SCI [20~40%, 2005 SCI Ranking:14/49 (Oral Sciences); Impact Factor:1.784] (corresponding author) (3x5x4=+60) 50.Shin-Da Lee, Wei-Wen Kuo,Ding-Yu Lin, James A Lin,Wu-Hsien Kuo, Hsi-Hsien Hsu, Jian-Zhi Chen, Chieh-Hsi Wu, Jer-Yuh Liu,Yu-Lan Yeh, Chih-Yang Huang.Role of calcineurin in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. J Biomedical Science2006, Mar;13(2):251-60.SCI [2005SCI Impact Factor: 1.995] (corresponding author) (3x5x4(NSC加重計分)=+60) 51.Erh-Jung Huang, Cheng-Chung Wu, Hsien-Ping Huang, Hsi-Hsien Hsu, Jer-Yuh Liu, Chung-Sheng Lin, Yan-Zin Chang, James A Lin, Chin-Chuan Tsai, Wei-Wen Kuo, Chih-Yang Huang.Apoptotic and anti-proliferative effects of estrogen and estrogen-like compounds in the Hep3B cell line. Moelcular and cellular Biochemistry.2006, 290(1-2):1-7SCI [NSC 90-2314-B-075A-018]. [60~80%, 2005 SCI Impact Factor:1.681] (corresponding author) (3x5x1.5= +22.5) 52.Shin-Da Lee,Wei-Wen Kuo, Wu-Hsien Kuo, Tsung-Ho Ying,Chu-Ming Huang, Ping-Chun Li, Hsi-Hsien Hus, Min-Chi Lu, James A Lin, Hua Ting, Chih-Yang Huang.Role of MEK in Porphyromonas gingivalis-induced myocardial cell hypertrophy and apoptosis. European J. of Oral Science2006, Apr;114(2):154-9. SCI [20~40%, 2005 SCI Ranking:14/49 (Oral Sciences); Impact Factor:1.784] (corresponding author) (3x5x4=+60) 53.Erh-Jung Huang, Cheng-Chung Wu, Min-Chi Lu, Jer-Yuh Liu,Jiunn-Liang Ko, James A Lin, Li-Mien Chen, Chih-Yang Huang, Wei-Wen Kuo.Opposing action of estrogen receptors αand β on tumor necrosis factor-α gene expression and Caspase-8-mediated apoptotic effects in HA22T cells. Molecular and cellular Biochemistry.2006, 287(1-2):137-145;[Epub ahead of print] SCI [NSC 92-2314-B-075A-014]. [2005 SCI Impact Factor:1.681] (Co-corresponding author) (3x5x1.5=+22.5) 54.Shin-Da Lee, Chih-Yang Huang, Win-Tom Shu, Ter-Hsin Chen, James A Lin, Jer-Yuh Liu, Hsi-Hsien Hsu, Chung-Sheng Lin, Chung-Jung Liu, Wei-Wen Kuo*, Li-Mien Chen *. Pro-inflammatory states and IGF-I level in ischemic heart disease with low or high serum iron. Clinica Chimica Acta. 2006, 370:50-56, SCI [20%~40%, 2005 SCI Ranking:5/23 (Medicine Lab); Impact Factor: 2.129] (3x3x4=+36). 55.Hsi-Hsien Hsu, Sue-Fei Cheng, Li-Mien Chen, Jer-Yu Liu, Chun-Hsien Chu, Yi-Jiun Weng, Zih-Ying Li, Chung-Sheng Lin, Shin-Da Lee, Wei-Wen Kuo*, Chih-Yang Huang*Over-expressed estrogen receptor-α up-regulate hTNF-α gene expression and down-regulate β-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cell. Molecular and cellular Biochemistry. 2006,Sep;289(1-2):101-9.SCI [SCI: 60%~80%; Impact Factor:1.681] (corresponding author) (3x5x1.5=+22.5) 56.Hsi-Hsien Hsu, Sue-Fei Cheng, Cheng-Chung Wu, Chun-Hsien Chu, Yi-Jiun Weng, Chung-Sheng Lin, Shin-Da Lee, Hung-Chien Wu, Chih-Yang Huang*, Wei-Wen Kuo* Apoptotic effects of over-expressed estrogen receptor-βon LoVo colon cancer cell is mediated by p53 signalings in a ligand-dependent manner. Chinese J. of Physiol.2006, 49(2): 110-116.SCI.[2005 SCI Impact Fact: 0.463] (Co-corresponding author) (3x5x2(NSC加重計分)=+30) 57.Gwo-Ping Jong, Tsochiang Ma, Pesus Chou, Mu-Hsin Chang, Chieh-His Wu, Ping-Chun Li, Shin-Da Lee, Jer-Yuh Liu Wei-Wen Kuo, Chih-Yang Huang Serum MMP-9 activity as the marker of diagnosing the developing heart failure from post MI patients. Chinese J. of Physiol.2006,49(2):9-15. SCI [2005 SCI Impact Fact: 0.463] (corresponding author) (3x5x2(NSC加重計分)=+30) 58.Shin-Da Lee, Sheng-huang Chang, Wei-Wen Kuo, James A Lin, Chu-Ming Huang, Min-Chi Lu,Li-Ming Chen, His-Hsien Hsu, Chin-Kun Wang,Chih-Yang Huang Porphyromonas gingivalis-induced cardiac cell apoptosis was majorly co-activated by p38 and ERK pathways.J Periodont Res. 2006, 41(1):39-46. SCI [20%, 2005 SCI Ranking (Oral Sciences); Impact Factor:1.947](corresponding author) (3x5x5= +75) 59.Shin-Da Lee, Wei-Wen Kuo, Chieh-His Wu, Yueh-Min Lin, James A Lin, Min-Chi Lu, Ai-Lun Yang, Jer-Yuh Liu, Shyi-Gang P. Wang, Chung-Jung Liu,Hsi-Hsien Hsu, Chih-Yang Huang.Effects of short-term and long-term Hypobaric Hypoxia on Bcl2 family in rat heart.International J. of Cardiology. 2006, 108(3):376-384. SCI [40%~50%, 2005 SCI Ranking:32/72 (Cardiovascular System); Impact Factor:1.765] (corresponding author) (3x5x3=+45) 60.Erh-Jung Huang, Wei-Wen Kuo, Yuh-Jyuan Chen, Ter-Hsin Chen, Mu-Hsin Chang, Min-Chi Lu, Bor-Show Tzang, Hsi-Hsien Hsu,Chih-Yang Huang, Shin-Da Lee. Homocysteine and other biochemical parameters in Type 2 diabetes mellitus with different diabetic duration or diabetic retinopathy. Clinica Chimica Acta.2006, 366:293-298. SCI [20%~40%, 2005 SCI Ranking:5/23 (Medicine Lab); Impact Factor: 2.129] (Co-corresponding author) (3x5x4=+60). 61.Shin-Da Lee, Li-Ming Chen, Wei-Wen Kuo, Win-Tom Shu, James A Lin, Chu-Ming Huang, Min-Chi Lu, Wu-Heien Kuo, Ter-Hsin Chen,Chih-Yang Huang.Serum Interleukin-10, Insulin-like growth factor-axis and MMPs in the patients with rheumatic heart disease and acute rhematoid arthritis. Clinica Chima Acta.2006; May;367(1-2):62-8.. SCI [20%~40%, 2005 SCI Ranking:5/23 (Medicine Lab); Impact Factor: 2.129] (corresponding author) (3x5x4=+60). 62.Yi-Hsien Hsieh, Trang-Tiau Wu, Jen-Hsiang Tsai, Chih-Yang Huang, Yih-Shou Hsieh, Jer-Yuh Liu. PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells. Biochem Biophys Res Commun. 2006;339(1):217-225, SCI [20%~40%, 2005 SCI Ranking:21/65 (Biophysics); Impact Factor: 3.000] (3x0.5x4=+6). 63.Wu TT, Hsieh YH, Wu CC, Tsai JH, Hsieh YS, Huang CY,Liu JY.Overexpression of Anion Exchanger 2 in Human Hepatocellular Carcinoma. Chin J Physiol.2006; 49(4):192-198, SCI[2005 SCI Impact Fact: 0.463] (3x0.5x2(NSC加重計分)=+3) ------------------------------------------------------------------------------------------------------------ 64.Wei-Wen Kuo, Chieh-His Wu, Shin-Da Lee, James A Lin, Chia-Yih Chu, Jin-Ming Hwang, Kwo-Chang Ueng, Mu-Hsin Chang, Yu-Lan Yeh, Chau-Jong Wang, Jer-Yuh Liu, Chih-Yang Huang.Second-hand smoke-induced cardiac fibrosis is Fas-death-receptor apoptotic pathway-related without mitochondria-dependent pathway involvement in rats. Enviromental Health Prospective, 2005; 113(10):1349-1353. SCI (corresponding author). [Top 1, 2005 SCI Ranking:1/134 (Environmental Sciences); Impact Factor:5.842] (3x5x5.842=+87.63) 65.Wei-Wen Kuo, Jer-Yuh Liu, Jia-Ping Wu, Kwo-Chang Ueng, Jyh-Cherng Shyu, Jen-Hsiang Tsai, Yi-Hsien Hsieh, Mu-Hsin Chang, Hsi-Hsien Hsu, Chung-Jung Liu, Chih-Yang Huang. 17β-Estradiol reduces cardic hypertrophy through the up regulation of PI3K/Akt and the suppression of calcineurin/NF-AT3 signaling pathways in rats. Life Science,2005;78(4):347-356. (*corresponding author) [NSC 90-2320-B-040-030]. [20%~40%, 2005 SCI, Ranking:28/72 (Medicine-research); IF:2.521] (3x5x4=+60) 66.Wei-Wen Kuo, Chia-Yih Chu, James A Lin, Jer-Yuh Liu, Kwo-Chang Ueng, Shin-Da Lee, Dennis Jine-Yuan Hsieh, Hsi-Hsien Hsu, Li-Ming Chen, Chih-Yang Huang.Impaired IGF-I signaling of hypertrophic hearts in the development phase of hypertension in genetically hypertensive rat. Cellular Biochemistry and Function, 2005;23:325-331.SCI (corresponding author)..----[60~80%, 2005 SCI Impact Factor:1.36] (3x5x1.5= +22.5) 67.Wei-Wen Kuo, Chia-Yih Chu, Chieh-His Wu, James A. Lin, Jer-Yuh Liu, Yi-Hsien Hsieh,Chu-Hsien Chu,Ding-Y u Lin, Hsi-Hsien Hsu, Chih-Yang Huang.The profile of cardiac cytochrome c oxidase (COX) expression in an accelerated cardiac hypertrophy model in rats.J. of Biomedical Science,2005, 12(4):601-610,SCI (corresponding author)[NSC 89-2320-B-040-053].[2005SCI Impact Factor: 1.995] (3x5x4(NSC加重計分)=+60) 68.Huang CY, Chen JH, Tsai CH, Kuo WW, Liu JY, Chang YC Regulation of extracellular signal-regulated protein kinase signaling in human osteosarcoma cells stimulated with nicotine. J Periodont Res. 2005;40;176-181 SCI (first author)[20%, 2005 SCI Ranking (Oral Sciences); Impact Factor:1.947](3x5x5= +75) 69.T-B Lin, M-J Lo, C-Y Huang, H Ting, and S-D Lee. GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. International Journal of Obesity & Related Metabolic Disorders. 2005, 29(2):188-195 SCI [Top 10%, 2004 SCI Ranking: 4/53(Nutrition&Dietetics); Impact Factor: 4.482](3x1x5= +15) 70.Tsai JH, Tsai MT, Su WW, Chen YL, Wu TT, Hsieh YS, Huang CY,Yeh KT, Liu JY.Expression of protein kinase C alpha in biopsies and surgical specimens of human hepatocellular carcinoma. Chin J Physiol.2005 Sep 30;48(3):139-43, SCI[2005 SCI Impact Fact: 0.463] (3x0.5x2(NSC加重計分)=+3) 71.Chih-Yang Huang, Wei-Wen Kuo, Pin-Ju Chueh, Chien-Tang Tseng, Ming-Yung Chou, Jaw-Ji Yang. Transforming growth factor-βinduces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK.Biochemical and Biophysical Research Communications. 2004, 324:424-431 SCI (first author). [20%~40%, 2005 SCI Ranking:21/65 (Biophysics); Impact Factor: 3.000] (3x5x4=+60). 72.Chih-Yang Huang, Pin-Ju Chueh, Chien-Tang Tseng, Kuan-Yu Liu, Hsiao-Ya Tsai, Wei-Wen Kuo, Ming-Yung Chou, Jaw-Ji Yang. ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells.Biochemical and Biophysical Research Communications. 2004, 324:973-980SCI (first author).[20%~40%, 2005 SCI Ranking:21/65 (Biophysics); Impact Factor: 3.000] (3x5x4=+60). 73.Hung-Chien Wu, Jaung-Geng Lin, Chun-Hsien Chu, Chung-Gwo Chang, Yung-Hsien Chang, Ching-Liang Hsieh, Angela Hsin-Chieh Tsai, Kwo-Chang Ueng, Wei-Wen Kuo, Jer-Yuh Liu, Chih-Yang Huang. The effects of acunpuncture on cardiac muscle cells and blood pressure in spontaneous hypertensive rats. Acunpuncture & Electro-Therapeutics RES., INT. J.2004, 29:83-95, SCI (corresponding author)[2005 SCI Ranking: 196/200 (Neuroscience); Impact Factor: 0.132] (3x5x1.5=+22.5) 74.Tzu-Chun Cheng, Chun-Chia Huang, Chung-I Chen, Chung-Shine Liu, Yih-Shou Hsieh, Chih-Yang Huang, Maw-Sheng Lee, Jer-Yuh Liu. Leukemia Inhibitory Factor Antisense Oligonucleotide Inhibits the Development of Murine Embryos at Preimplantation Stages. Biology of Reproduction, 2004, 70:1270-1276. SCI, [2005 SCI Ranking: 3/24 (Neuroscience); Impact Factor: 3.583] (3x0.5x5=+7.5) 75.Trang-Tiau Wu, Jen-Hsiang Tsai, Ju-Hsin Tsai, Shou-Jen Kuo, Shi-Yau Yu, Chih-Yang Huang, Hai-Yang Hsieh, Yih-Shou Hsieh, Jer-Yuh Liu. Augmented release of MMP-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal tissue and fibroadenoma. Chinese J. of Physiol.2004, 46(1): 19-26 SCI[2005 SCI Impact Fact: 0.463] (3x0.5x2(NSC加重計分)=+3)