Adrenergic_Receptor抑制剂_激动剂_MCE

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that

are targets of the catecholamines, especially norepinephrine and

epinephrine. Many cells possess these receptors, and the binding of a

catecholamine to the receptor will generally stimulate the

sympathetic nervous system. The sympathetic nervous system is

responsible for the fight-or-flight response, which includes widening

the pupils of the eye, mobilizing energy, and diverting blood flow

from non-essential organs to skeletal muscle. There are two main

groups of adrenergic receptors, α and β, with several

subtypes. α receptors have the subtypes α1 and

α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor Inhibitors & Modulators

Bisoprolol is a selective type (beta)1 adrenergic receptor blocker.

((plusmn))-Ephedrine Hcl is a sympathomimetic amine, commonly used as a stimulant, decongestant, appetite suppressant, and to treat Acebutolol Hydrochloride is a (beta)-adrenergic receptors antagonist

used in the treatment of hypertension, angina pectoris and cardiac Adrenalone hydrochloride is a selective (alpha)1-adrenoceptor agonist, used as a topical vasoconstrictor and hemostatic, used to Alfuzosin is an (alpha)1 adrenergic receptor antagonist used to treat Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used alpha-adrenergic agonist activity, interaction with octopamine

receptors of the central nervous system and inhibition of monoamine Cat. No.: HY-B0076

Cat. No.: HY-B0980

Cat. No.: HY-17497A

Cat. No.: HY-B1308

Cat. No.: HY-B0192

Cat. No.: HY-B0192A

Cat. No.: HY-A0275

Cat. No.: HY-B1111

Atipamezole(MPV1248) is an alpha-adrenoceptor antagonist with Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonist

with high affinity and selectivity for the alpha 2-receptor.

B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist,

(alpha)2-adrenoceptor agonist and 5-HT3 receptor antagonist, which Bambuterol is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline.

Bambuterol Hcl is a long acting beta-adrenoceptor agonist (LABA)used in the treatment of asthma; it also is a prodrug of terbutaline.

Betaxolol is a selective beta1 adrenergic receptor blocker used in the Betaxolol Hydrochloride is a selective beta1 adrenergic receptor blocker used in the treatment of hypertension and glaucoma.

Cat. No.: HY-17498

Cat. No.: HY-12380A

Cat. No.: HY-12380

Cat. No.: HY-A0008

Cat. No.: HY-17501

(KWD-2183; (±)-Bambuterol hydrochloride

Cat. No.: HY-17501A

Cat. No.: HY-B0381

Cat. No.: HY-B0381A

Carvedilol is a non-selective beta blocker/alpha-1 blocker with an Clonidine Hydrochloride is a centrally acting alpha-agonist Deoxycorticosterone acetate is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a Detomidine produce dose-dependent sedative and analgesic effects,Detomidine hydrochloride produce dose-dependent sedative and

analgesic effects, is a nonnarcotic, synthetic (alpha)2-adrenergic Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2receptor, which is used in veterinary medicine for its analgesic and DL-Epinephrine(DL-Adrenaline) is a hormone and a neurotransmitter.

Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of (beta)1 receptors of the Cat. No.: HY-B0006A

Cat. No.: HY-B0409A

Cat. No.: HY-B1472

Cat. No.: HY-B0163

Cat. No.: HY-B0163A

((+)-Medetomidine hydrochlo

Cat. No.: HY-17034A

Cat. No.: HY-B0447

Cat. No.: HY-15746

Esmolol Hydrochloride is a beta adrenergic receptor blocker.

Fenoterol is a (beta) 2 adrenergic agonist designed to open up the airways to the lungs, is classed as sympathomimetic (beta)2 agonist Fenoterol hydrobromide is a (beta) 2 adrenergic agonist designed to

open up the airways to the lungs, is classed as sympathomimetic Fenspiride Hcl is an (alpha) adrenergic and H1 histamine receptor Formoterol(Arformoterol) is a novel highly (beta)2-selective

adrenergic agonist and holds promise as a (beta)2-agonist that could Formoterol fumarate(Foradil) is a potent, selective and long-acting Guanabenz Acetate is an alpha-2 selective adrenergic agonist used Cat. No.: HY-B1392

Cat. No.: HY-B0976

(Fenoterol bromide; Th-1165a; Phenotero

Cat. No.: HY-B0976A

Cat. No.: HY-A0027

Cat. No.: HY-B0010A

Cat. No.: HY-B0010

Cat. No.: HY-B0566

Cat. No.: HY-17416A

Hydrocortisone 17-butyrate is an adrenocortico hormone.

ICI 118551 Hcl is a highly selective (beta)2 adrenergic receptor

antagonist (Ki values are 1.2, 120 and 257 nM at (beta)2, (beta)1 and Indacaterol Maleate is an ultra-long-acting (beta)-adrenoceptor Indoramin D5 is deuterium labeled Indoramin, which is a piperidine Isoprenaline Hydrochloride is a non-selective beta-adrenergic Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM,α2-adrenergic receptors) psychoactive drug used as a sympatholytic Cat. No.: HY-B0983

Cat. No.: HY-13951

Cat. No.: HY-14299

Cat. No.: HY-14299A

Cat. No.: HY-12760S

Cat. No.: HY-B0468

Cat. No.: HY-B0162A

Cat. No.: HY-B0225

L-Epinephrine(L-Adrenaline) is a hormone and a neurotransmitter.L-Epinephrine Bitartrate is alpha- and beta-adrenergic receptor Labetalol hydrochloride is a mixed alpha/beta adrenergic antagonist Levosalbutamol tartrate(levalbuterol) is the R-enantiomer of the

short-acting (beta)2-adrenergic receptor agonist salbutamol.

Levobetaxolol hydrochloride is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating Lofexidine hydrochloride is an (alpha)2A-adrenergic receptor agonist, commonly used to alleviate the physical symptoms of heroin and

(alpha)2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for Medetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and

Cat. No.: HY-B0447B Cat. No.: HY-B0447A

(AH-5158 hydrochloride; Sch-15719W; Tra

Cat. No.: HY-B1108Cat. No.: HY-17457

Cat. No.: HY-B0381B (Britlofex; Baq-168; Lofetensin; Loxaco

Cat. No.: HY-B1052

Cat. No.: HY-17034Cat. No.: HY-17034B

Metoprolol (Toprol) is a selective (beta)1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially Metoprolol Succinate (Toprol XL) is a selective (beta)1 receptor blocker used in treatment of several diseases of the cardiovascular Metoprolol is a cardioselective β1-adrenergic blocking agent.

Mirabegron(YM178) is a selective (beta)3-adrenoceptor agonist with Nadolol D9 is the deuterium labeled Nadolol(SQ-11725), which is a Naftopidil (Flivas), a selective α1-adrenergic receptor antagonist or Naphazoline HCl is an ocular vasoconstrictor and imidazoline Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8Cat. No.: HY-17503

Cat. No.: HY-17503A

Cat. No.: HY-17503B

Cat. No.: HY-14773

Cat. No.: HY-B0804S

(Flivas; KT-611; BM-15275; KT611; BM15275; KT 611; BM

Cat. No.: HY-B0391

Cat. No.: HY-B0446

Cat. No.: HY-B0203

Octopamine Hydrochloride is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic Oxymetazoline Hydrochloride is a selective alpha-1 agonist and Pardoprunox(SLV-308) is a novel partial dopamine D2 and D3

receptor agonist and serotonin 5-HT1A receptor agonist; D2 (pKi =8.1) and D3 receptor (pKi = 8.6) partial agonist (IA = 50% and 67%,respectively) and 5-HT1A receptor (pKi = 8.5) full agonist (IA =100%); also binds to D4 (pKi = 7.8), (alpha)1-adrenergic (pKi = 7.8),Penbutolol sulfate is able to bind to both beta-1 adrenergic

receptors and beta-2 adrenergic receptors (the two subtypes), thus sympathomimetic drugused in the treatment of high blood pressure.

Perphenazine is a typical antipsychotic drug, inhibits 5-HT2A receptor

(5-HT2A), Alpha-1A adrenergic receptor ((alpha)1A), Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor (H1) with Phenoxybenzamine HCl is a non-specific, irreversible alpha Phentolamine Mesylate is a nonselective alpha-adrenergic Pindolol is a nonselective (beta)-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak Cat. No.: HY-B0528A

Cat. No.: HY-B0427A

Cat. No.: HY-14958

Cat. No.: HY-B1154

Cat. No.: HY-A0077

Cat. No.: HY-B0431A

(Regitine mesylate; Phentolamine methan

Cat. No.: HY-B0362A

Cat. No.: HY-B0982

Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug

used to treat high blood pressure and anxiety, PTSD, and panic Pronethalol is a non-selective beta-adrenergic blocking agent,protect against and to reverse Digitalis-induced ventricular Propranolol Hydrochloride is a widely used non-cardioselective

Salbutamol is a short-acting (beta)2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma Salbutamol Hemisulfate is a short-acting (beta)2 adrenergic receptor Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR)Salmeterol(GR 33343X) xinafoate is a long-acting beta2-adrenergic receptor agonist drug that is prescribed for the treatment of asthma (Furazosin hydrochloride; Minipress hyd

Cat. No.: HY-B0193A

Cat. No.: HY-B1238

Cat. No.: HY-B0573

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Cat. No.: HY-B0436

Cat. No.: HY-14302

Cat. No.: HY-17453

Silodosin (Rapaflo; KMD-3213) is an (alpha)1-adrenoceptor antagonist with high uroselectivity; In treatment of dysuria.

Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in Synephrine Hcl(Oxedrine) is an alkaloid; synephrine produces most of its biological effects by acting as an agonist at adrenergic receptors.

Tamsulosin hydrochloride((R)-(-)-YM12617;LY253351) is a selective Tapentadol Hcl is a centrally acting oral analgesic with opioid and Terazosin is a selective alpha1-antagonist used for treatment of

Terazosin Hydrochloride dihydrate is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia Cat. No.: HY-10122

Cat. No.: HY-B0437

Cat. No.: HY-N0132A

Cat. No.: HY-B0661

Cat. No.: HY-B0661A

Cat. No.: HY-70042A

Cat. No.: HY-B0371

(Hytrin hydrochloride dihyd

Cat. No.: HY-B0371A

Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.

Tizanidine hydrochloride is an (alpha)2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic Tolazoline(NSC35110; Imidaline) is a non-selective competitive Tolazoline(NSC35110; Imidaline) Hcl is a non-selective competitive UK 14,304 is a full (alpha)2-adrenergic receptor ((alpha)2-AR) agonist.

UK 14,304 is a full (alpha)2-adrenergic receptor ((alpha)2-AR) agonist.

Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor Vilanterol (GW642444; GW 642444X) is a novel, inhaled, long-acting (beta)(2) agonist with inherent 24-h activity under development as a once-daily combination therapy with an inhaled corticosteroid for Cat. No.: HY-B0194

Cat. No.: HY-B0194A

Cat. No.: HY-A0066

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Cat. No.: HY-B0659

Cat. No.: HY-B0659A

Cat. No.: HY-B0354A

(GW 642444X; GW 642444; GW642444X; GW642444; GW-642444

Cat. No.: HY-14300

Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.

Xylometazoline Hydrochloride is an α-adrenoceptor agonist

Yohimbine is a potent and relatively nonselective alpha 2-adrenergic (Rompun; BAY1470 hydrochloride; BAY-147

Cat. No.: HY-B0443A

Cat. No.: HY-B0475

Cat. No.: HY-12715