磺胺嘧啶钠在家兔药动学参数的测定与计算

药品 012

34X=SD-Na含量010203040Y=OD 52500.142

0.230.2580.349

X-时间（min）

OD525

SD含量（ug）

Y-血药浓度（ug∕ml）LgY

000

50.41151.81818182518.18181822.714482100.31739.61038961396.10389612.597809150.34943.76623377437.66233772.641139200.33742.20779221422.07792212.625393300.26933.37662338333.76623382.523442600.295

36.75324675

367.5324675

2.565296

K(min -1)0.0050666t 1/2(min)136.778116C 0(ug/ml)458.775271Vd=DO/C 0(ml/kg)0.87188658C1(ml/kg/min)0.0044175AUC

90548.9422

DO(ug/kg)

400

实验一：SD-Na标准曲线的制备及回归方程的计算实验二：SD-Na血药浓度测定

50

0.468