第四章《抗体》练习题

第四章《抗体》练习题

一、单项选择题

1.抗体与抗原结合的结构域是················································()

A、VH

B、VL

C、CH

D、VH和VL

2.IgG与C1q结合的结构域是················································()

A、CH1

B、CH2

C、CH3

D、VH和VL

3.IgM与C1q结合的结构域是················································()

A、CH1

B、CH2

C、CH3

D、VH和VL

4.IgG与吞噬细胞或NK细胞表面FcγR结合的结构域是··························()

A、CH1

B、CH2

C、CH3

D、VH和VL

5.血清中含量最高的Ig是···················································()

A、IgA

B、IgM

C、IgG

D、IgD

6.与抗原结合后激活补体能力最强的Ig是·····································()

A、IgA

B、IgM

C、IgG

D、IgD

7.能通过胎盘的Ig是·······················································()

A、IgA

B、IgG

C、IgM

D、IgE

8.脐血中含量增高提示胎儿有宫内感染的Ig是·································()

A、IgA

B、IgM

C、IgG

D、IgD

9.在初次感染病原微生物后,机体最早产生的抗体是·····························()

A、IgA

B、IgM

C、IgG

D、IgD

10.分子量最大的Ig是······················································()

A、IgA

B、IgM

C、IgG

D、IgD

11.新生儿从母乳中获得的抗体是·············································()

A、IgA

B、IgM

C、IgG

D、SIgA

12.产生抗体的细胞是·······················································()

A、T 细胞

B、B细胞

C、浆细胞

D、NK细胞

13.sIgA的组成为··························································()

A、二个IgA单体与一个J链

B、二个IgA单体与一个J链和一个分泌片

C、一个IgA单体与一个J链

D、一个IgA单体与一个J链和一个分泌片14.能与肥大细胞表面FcεR结合,介导Ⅰ型超敏反应的Ig是·······················()

A、IgA

B、IgM

C、IgG

D、IgE

15.天然ABO血型抗体属于··················································()

A、IgA

B、IgM

C、IgG

D、IgD

16.具有J链结构的Ig是·····················································()

A、sIgA、IgG

B、IgM、sIgA

C、IgG、IgD

D、IgD、IgE

17.J链合成缺陷后受影响的Ig是·············································()

A、IgG和IgE

B、IgM

C、IgA

D、IgM和sIgA 18.参与黏膜局部抗感染的Ig是··············································()

A、IgA

B、IgM

C、sIgA

D、IgG

19.抗体分子基本结构的组成是···············································()

A、2条重链和2条轻链

B、1条重链和1条轻链

C、2条相同的重链和2条相同的轻链

D、4条相同的肽链

20.下列不属于抗体的功能为·················································()

A、与抗原结合

B、激活补体

C、杀灭细胞

D、调理作用

21.合成sIgA分泌片的细胞是················································()

A、巨噬细胞

B、血管内皮细胞

C、浆细胞

D、黏膜上皮细胞22.IgG易被蛋白水解酶作用的部位是·········································()

A、铰链区

B、VH和VL

C、CH1

D、CH2

23.成熟B细胞的BCR的Ig类型是············································()

A、mIgA和mIgM

B、mIgM和mIgD

C、mIgG和mIgE

D、mIgE和mIgD 24.具有CH4结构域的Ig为··················································()

A、sIgA和IgM

B、IgM和IgD

C、IgM和IgE

D、IgE和IgG 25.关于抗体,下列描述错误的是··············································()

A、抗体都是 球蛋白

B、抗体主要存在于体液中

C、抗体能与相应抗原特异性结合

D、抗体由浆细胞产生

26.介导NK细胞等效应细胞产生ADCC效应的Ig主要是·························()

A、IgA

B、IgD

C、IgG

D、IgM

27.关于Ig的铰链区,下列表述错误的是·······································()

A、位于CH1和CH2之间

B、富含脯氨酸

C、易于伸展弯曲

D、五类Ig铰链区相同

28.sIgA分子中分泌片的主要功能是··········································()

A、连接2个IgA单体

B、维持sIgA的立体构象

C、保护sIgA免遭蛋白酶的水解

D、促进抗体与抗原的结合

29.抗体发挥中和毒素作用主要依赖其·········································()

A、C区的作用

B、调理作用

C、ADCC作用

D、V区的作用30.IgM的实际抗原结合价为·················································()

A、1价

B、2价

C、5价

D、10价

二、填空题

1.抗体分子的基本结构是由两条相同的和两条相同的通过链间__________连接而成的四肽链结构。

2.IgA、IgM、IgG、IgE、IgD相应的重链分别为、、、、。

3.五类Ig中,血清含量最高的是,具有J链和分泌片的是,分子量最大的是,能介导Ⅰ型超敏反应的是,能通过胎盘的是。

4.免疫球蛋白轻链可分为型和型。

5.用木瓜蛋白酶水解IgG可得到两个相同的片段和一个片段;用胃蛋白酶水解IgG可获得一个能与抗原结合的片段和无生物学活性的片段。

6.IgG铰链区位于与之间的区域,其补体(C1q)结合点位于。

7.具有J链结构的免疫球蛋白有和。

8.sIgA由二个IgA单体与和组成,主要存在于外分泌液中,在局部黏膜免疫中发挥重要作用。

三、名词解释

抗体Ig CDR 独特型(Id)抗体的调理作用

ADCC作用单克隆抗体基因工程抗体

四、简答题

1.简述免疫球蛋白的基本结构。

2.简述IgG分子的结构域组成及各结构域分别有何功能。

3.试述IgG的主要免疫学特性及功能。

4.试述IgM的主要免疫学特性及功能。

5.试述sIgA的分子结构组成、分布及主要免疫学功能。

五、问答题

1.试述抗体的功能。

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