Vaniprevir_923590-37-8_DataSheet_MedChemExpress

Product Name:

Vaniprevir CAS No.:

923590-37-8

Product Data Sheet

Cat. No.:

HY-10243MWt:

757.94Formula:

C38H55N5O9S Purity :

>98%

Solubility:Mechanisms:Biological Activity:

Pathways:Anti-infection; Target:HCV

Pathways:Metabolism/Protease; Target:HCV NS3/4A Protease

DMSO

g y Vaniprevir (MK-7009) is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A

protease.

IC50 Value:

Target: HCV NS3/4A Protease; HCV vaniprevir (MK-7009) is a macrocyclic hepatitis C virus NS3/4a protease inhibitor, is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. vaniprevir (MK-7009) has good plasma exposure and excellent liver exposure in multiple species.

References:

[1]. Liverton, Nigel J.; Carroll, Steven S.; Di Muzio, Jillian;.MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease. Antimicrobial Agents and Chemotherapy (2009), Volume

Date 2010, 54(1), 305-311.[2]. Kong J, Chen CY, Balsells-Padros J, Cao Y, Dunn RF, Dolman SJ, Janey J, Li H, Zacuto []g y

MJ.Synthesis of the HCV protease inhibitor Vaniprevir (MK-7009) using ring-closing metathesis

strategy.J Org Chem. 2012 Apr 20;77(8):3820-8. Epub 2012 Apr 10.[3]. Manns MP, Gane E, Rodriguez-Torres M, Stoehr A, Yeh CT, Marcellin P, Wiedmann RT, Hwang PM, Caro L, Barnard RJ, Lee AW; for the MK-7009 Protocol 007 Study Group.Vaniprevir with pegylated interferon alpha-2a and ribavirin in treatment-na?ve patients with chronic hepatitis C: A

randomized phase II study.Hepatology. 2012 Sep;56(3):884-893.[4]. Song ZJ, Tellers DM, Journet M, Kuethe JT...

Caution: Not fully tested. For research purposes only

Medchemexpress LLC

https://www.wendangku.net/doc/a45151098.html,

18W i l k i n s o n W a y , P r i n c e t o n , N J 08540,U S A

E m a i l : i n f o @m e d c h e m e x p r e s s .c o m W e b : w w w .m e d c h e m e x p r e s s .c o m