Curcumin_458-37-7_DataSheet_MedChemExpress

P d D Sh

Product Name:

Curcumin CAS No.:

458-37-7Cat. No.:

HY-N0005Product Data Sheet MWt:

368.38Formula:

C21H20O6Purity :>98%

Solubility:

DMSO

Mechanisms:

Biological Activity:

Curcumin is a natural phenolic compound with impressive antioxidant properties. Curcumin is Pathways:NF-kB; Target:Keap1-Nrf2recently proved to exert its chemopreventive effects partly through the activation of nuclear factor

(erythroid-2 related) factor 2 (Nrf2).

IC50 Value:

Target: Nrf2 Curcumin possesses chemopreventive properties against several types of cancer, but the molecular mechanisms by which it induces apoptosis of cancer cells and inhibits cancer cell

proliferation are not clearly understood. in vitro: curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal regulated kinase 1/2signaling Curcumin inhibited cell proliferation which was References:

[1]. Gao S, Duan X, Wang X, Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion Food Chem Toxicol 2013Jul 18pii:S0*******(13)004870extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and

downregulation of cyclin D1 [2]. Treatment of AGS and HT-29 cells with curcumin enhanced the cleavage of proc...

and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)00487-0.

[2]. Nasiri M, Zarghami N, Koshki KN, Curcumin and Silibinin Inhibit Telomerase Expression in

T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53.[3]. Cao A, Li Q, Yin P, Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress.

Apoptosis. 2013 Jul 24. [Epub ahead of print][4]. Jiang H, Wang Z, Wang Y, Antidepressant-like effects of curcumin in chronic mild stress of rats:Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiat...

Caution: Not fully tested. For research purposes only

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