柴黄益肾颗粒对糖尿病肾病大鼠肝损伤保护作用的实验
?2813?中华中医药杂志(原中国医药学报)2012年11月第27卷第11期CJTCMP,November 2012,Vol.27,No.11
Respiratory Diseases,2008,31(3):177-185
[4] 周仲英,金实,李明富,等.中医内科学.7版.北京:中国中医药出
版社,2004:87
ZHOU Zhong-ying,JIN Shi,LI Ming-fu,et al.Internal Medicine of TCM.7th edition.Beijing:China Press of TCM,2004:87
[5] SFDA.中药新药临床研究指导原则.北京:中国医药科技出版
社,2002:64-66
SFDA.Guidelines on Clinical Research of New Drugs in Chinese Medicine(on trial).Beijing:China Medical Science and Technology Press,2002:64-66
[6] 张益康,黄艳,刘鑫,等.补肾活血汤治疗虚哮30例临床观察.湖
南中医杂志,2008,24(2):23-24
ZHANG Yi-kang,HUANG Yan,LIU Xin,et al.Clinical observation of tonifying kidney and activating blood decoction on 30 cases of asthma of deficiency syndrome.Hunan Journal of TCM,2008,24(2): 23-24
[7] 邹积宝,孙永强.中药穴位贴敷治疗支气管哮喘研究进展.中
医外治杂志,2009,18(1):52-53
ZOU Ji-bao,SUN Yong-qiang.Research progress of Chinese herb
acupoint application on bronchial asthma.Journal of External Therapy of TCM ,2009,18 (1):52-53
[8] 王顺玉.支气管哮喘治疗药物的临床评价.中国医药导报,
2009,6(11):147-148
WANG Shun-yu.Clinical evaluation of drugs on bronchial asthma.
China Medical Herald,2009,6(11):147-148
[9] 冯学英,王大伟.咳喘膏伏天贴穴对慢性支气管炎患者免疫
功能的影响.山东中医杂志,2001,20(7):405
FENG Xue-ying,WANG Da-wei.Effects of kechuan paste acupoint application during dog days on immunologic function of patients with chronic bronchitis.Shandong Journal of TCM,2001,20(7):405 [10] 邵长荣.激素依赖型哮喘的中医证治.江苏中医药,2007,
39(6):3-4
SHAO Chang-rong.TCM treatment on hormone dependent asthma.
Jiangsu Journal of TCM,2007,39(6):3-4
[11] 伍少冰.我国平喘药市场浅析.广东药学,2003,13(1):49-50
WU Shao-bing.Simple analysis of antiasthmatic drugs market in our country.Guangdong Pharmaceutical Journal,2003,13(1):49-50
（收稿日期：2011年7月22日）
·论著·
柴黄益肾颗粒对糖尿病肾病大鼠肝损伤保护
作用的实验研究
韩文兵1,2，李平2，张浩军2，赵婷婷2，李忻2，杨鑫2，路晓光2，古艳婷2，王红盼2，朱斌2
（1北京中医药大学，北京 100029；2中日友好医院，北京 100029）
摘要：目的：探讨柴黄益肾颗粒对实验性糖尿病肾病大鼠肝损伤的保护作用。方法：健康雄性Wistar大鼠112只，顺应性喂养3d后，随机分为假手术对照组12只，单侧肾切除组100只，造模成功后随机分为：模型组、柴黄益肾大、中、小剂量组、蒙诺组。观察柴黄益肾颗粒对大鼠肝重指数、血糖、血脂、24小时尿蛋白定量、肝组织糖原蓄积程度、肝组织Ⅰ、Ⅲ型胶原及肝组织病理的影响。结果：与模型组比较，柴黄益肾颗粒能够显著减低大鼠肝重指数（P<0.05），降低血清总胆固醇、甘油三酯以及尿液中24h尿蛋白定量（P<0.05）；与蒙诺组比较，柴黄益肾颗粒能够显著减轻大鼠肝组织糖原蓄积程度、炎症活动度，同时柴黄益肾颗粒抑制了Ⅰ、Ⅲ型胶原在肝组织中的表达。结论：柴黄益肾颗粒对糖尿病肾病大鼠肝损伤具良好的保护作用。
关键词：柴黄益肾颗粒（CHYS）；糖尿病肾病；肝损伤；Ⅰ型胶原；Ⅲ型胶原
基金资助：国家自然科学基金课题（No.30973911，No.81173422）
Protective effect of Chaihuangyishen Granule on liver injury in diabetic nephropathy rats HAN Wen-bing1, 2, LI Ping2, ZHANG Hao-jun2, ZHAO Ting-ting2, LI-Xin2, YANG Xin2, LU Xiao-guang2, GU Yan-ting2, WANG Hong-pan2, ZHU Bin2
( 1Beijing University of Chinese Medicine, Beijing 100029, China; 2China-Japan Friendship Hospital, Beijing 100029, China )
Abstract: Objective: To investigate the effect of Chaihuangyishen Granule (CHYS) to liver histological injury in diabetic nephropathy rats which were induced by Streptozotocin(STZ). Methods: After 3 days feed,Wistar rats were randomly divided into12 rats in sham control group and100 rats in uninephrectomy groups which were induced into diabetic modelby
通讯作者：李平，北京市朝阳区樱花东路2号中日友好医院临床医学研究所药物药理室，邮编：100029，电话：010-********
传真：010-********，E-mail：lp8675@yahoo. https://www.wendangku.net/doc/ff12382258.html,