低能量Q开关NdYAG激光对黄褐斑体表温度与黑素指数的影响

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低能量Q开关Nd:YAG激光对黄褐斑体表温度与黑素指数的影响

作者：蔡宏宋为民王毅侠金宪强沈静郑涵赵广

来源：《中国美容医学》2012年第05期

[摘要]目的：观察Q开关Nd:YAG激光治疗黄褐斑时皮肤体表的温度变化，探讨体表温度的改变与黑素指数的关系。方法：对22例黄褐斑患者使用Q开关Nd:YAG1064nm激光治疗，光斑直径6mm或8mm，能量密度2.0～3.3J/cm2，每周1次，12次为1个疗程。单次激光治疗前、治疗中、治疗后即刻用红外测温仪测量黄褐斑部位皮肤体表温度，并在治疗前、治疗6次、12次后使用皮肤多功能测试仪检测相应固定部位黑素指数。结果：黄褐斑皮损区单次治

疗后双面颊体表温度高于治疗前，但与正常皮肤相比无差异；激光治疗6次、12次后黑素指

数均显著性减少。结论：低能量Q开关Nd:YAG激光治疗黄褐斑后皮肤温度有一定程度升高，但并不引起明显光斑反应，治疗后黑素指数降低，表明温度并非导致激光光斑反应的唯一及主要因素，可能与Q开关激光激活黑素细胞内部的反应原件相关。

[关键词]黄褐斑；Q开关Nd:YAG激光；黑素指数；温度

[中图分类号]R758.4+2 [文献标识码]A [文章编号]1008-6455（2012）05-0793-03

Effect of melasma's temperature and melanin index treated by Q-switched laser

CAI Hong1, SONG Wei-min2, WANG Yi-xia1, JIN Xian-qiang2, SHEN Jing1, ZHENG Han2, ZHAO Guang1

(1.Department of Dermatology,The General Hospital of Air Force,Beijing

100141,China;2.Department of Dermatology,The Third People's Hospital of Hangzhou)

Abstract: Objective To investigate the effectiveness and temperature influences of 1064nm Q-switched neodymium-doped yttrium aluminum garnet (QS-Nd:YAG) laser treatment of melasma . Methods Twenty-two patients were treated with 1,064-nm QS-Nd:YAG laser, 6 or 8-mm spot size, 2.0- to 3.3-J/cm2 fluence for 12 sessions at 1-week intervals. The skin temperature and melanin index were evaluated by infrared thermometer and the skin multifunction ester at different time

point,respectively. Results After 12 laser treatments, statistically significant improvement of melasma from baseline was observed.However,there was no significant difference in temperature between after treatment area and control area. Conclusion Nd:YAG laser treatment for melasma produced