Anti-apoptotic treatment in mouse models of age-related hearing loss

Anti-apoptotic treatment in mouse models of age-

related hearing loss

Fengchan Han;Oumei Wang;Quanxiang Cai

【期刊名称】《中华耳科学杂志（英文版）》

【年(卷),期】2016(011)001

【摘要】Age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.

【总页数】6页(7-12)

【关键词】

【作者】Fengchan Han;Oumei Wang;Quanxiang Cai

【作者单位】a Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, 346 Guanhai Road, Yantai