03---中药复方治疗老年痴呆的用药规律分析_胡增峣

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Research progress of the impact of Chinese medicine on hippocampus based on the animal model of VD

Jing Xiaolong,Liu Jing,Ren Ying,Shen Xiuping

(Tianjin Center for drug evaluation and research,Tianjin300301)

Vascular dementia is common diseases in older persons,which is considered the second most common form of dementia after Alzheimer disease(AD).Recently,in the application of traditional Chinese medicine for the treatment of vascular dementia,many researchers have studied the learning and memory capacity of hippocampus in many aspects.In this paper,the research of the role of the hippocampus in tradi-tional Chinese medicine treatment of vascular dementia were reviewed for the past three years on the level of cellular and molecular mecha-nisms.

Key words vascular dementia;hippocampus;Chinese medicine

中药复方治疗老年痴呆的用药规律分析*

胡增峣,黄晏,刘港,刘芳,周文霞**,张永祥

(军事医学科学院毒物药物研究所,北京100850)

摘要目的:研究、总结中药复方治疗老年痴呆的用药规律,探寻中药材治疗老年痴呆的活性成分,为开发更合理的治疗老年痴呆组分中药提供一定的借鉴思路。方法:收集、整理治疗老年痴呆的中药复方,建立数据库,对其用药规律进行详细分析,查询常用中药材的活性成分,分析其改善认知等神经药理方面的作用。结果:132首复方共使用药材150味,使用频率居前的药材类别

*基金项目:国家自然科学基金青年科学基金项目(81100239,81202505)**通讯作者

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